Southeast Minnesota Vacations from $345

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

    Rest easy

    Plan, book, and manage your trip all in one place

Your Southeast Minnesota Vacation

Head off on your next adventure with a Southeast Minnesota vacation package, and leave knowing the finer details are organized. And with the ability to tailor your escape, it'll be one to remember. With so many things to explore on a trip to Southeast Minnesota, it can be hard to know where to begin. Kick off your journey in Rochester at Mayo Civic Center and Apache Mall — two popular attractions here. Another great city to add to your itinerary is Albert Lea. Don't miss Albert Lea City Arena and Fountain Lake. From the instant you book your Southeast Minnesota vacation to the second you come back home, Expedia has your back each step of the way.

The Latest Southeast Minnesota vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Minneapolis
Radisson RED Minneapolis Downtown
Graduate by Hilton Minneapolis
The Westin Minneapolis
Hyatt Regency Minneapolis
Don't see what you're looking for?
See all available trips from Columbus to Southeast Minnesota
View all trips

Where to stay in Southeast Minnesota

Find the best Southeast Minnesota areas and neighborhoods for the activities you enjoy most. Learn more about Southeast Minnesota

Discover the most popular places to visit in Southeast Minnesota

What to do in Southeast Minnesota

Southeast Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $138 total per night from Oct 23 to Oct 24
$138 total
Oct 23 - Oct 24
Total with taxes and fees
8.2/10 Very Good! (1,651 reviews)
"Very convenient to Mayo for us. The rooms are clean and comfortable. The staff are very helpful and cheerful. They are kind enough to store our luggage and keep our car in the ramp until our medical appts at Mayo are complete, even after checking out. The valet service is very helpful, especially ..."

Reviewed on Oct 9, 2025

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $136 total per night from Nov 10 to Nov 11
$136 total
Nov 10 - Nov 11
Total with taxes and fees
7.8/10 Good! (1,454 reviews)
"Nice hotel convenient for medical appointments ~ nice breakfast"

Reviewed on Oct 5, 2025

Kahler Inn and Suites - Mayo Clinic Area
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE, Rochester, MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Oct 19 to Oct 20
$84 total
Oct 19 - Oct 20
Total with taxes and fees
9.2/10 Wonderful! (196 reviews)
"Brand new everything was clean and working!"

Reviewed on Oct 6, 2025

Spark by Hilton Rochester South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Minnesota Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Minneapolis - St. Paul Intl. Airport (MSP)

More vacations you might like

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.